Sobre el grupo
Investigador Principal
Cristina Paules TejeroEquipo
Ana Medel Martínez, Jesús González Pérez, Juan Lerma Irureta, Natalia Abadía Cuchí, Pilar Maestro Quibus, Sonia Ruiz Lorente![](https://www.iisaragon.es/wp-content/uploads/2023/10/Foto106_grupo-MFH-scaled.jpg)
Hospital Clínico Universitario Lozano Blesa
Líneas de Investigación
Amenaza de parto prematuro
Diabetes gestacional
Programación fetal
Publicaciones mas relevantes
González J, Vilella M, Ruiz S, Iglesia I, Clavero-Adell M, Ayerza-Casas A, Matute-Llorente A, Oros D, Casajús JA, Pueyo V, Rodriguez G, Paules C. Impact of Suspected Preterm Labor during Pregnancy on Cardiometabolic Profile and Neurodevelopment during Childhood: A Prospective Cohort Study Protocol. Diagnostics (Basel). 2023 Mar 14;13(6):1101. doi: 10.3390/diagnostics13061101. PMID: 36980410; PMCID: PMC10047113.
Fabre M, Calvo P, Ruiz-Martinez S, Peran M, Oros D, Medel-Martinez A, Strunk M, Benito Ruesca R, Schoorlemmer J, Paules C. Frequent Placental SARS-CoV-2 in Patients with COVID-19-Associated Hypertensive Disorders of Pregnancy. Fetal Diagn Ther. 2021;48(11-12):801-811. doi: 10.1159/000520179. Epub 2021 Nov 18. PMID: 34794139; PMCID: PMC8678236.
Abadía-Cuchí N, Ruiz-Martínez S, Fabre M, Mateo P, Remacha Sienes M, Ventura Faci P, Bueno Sancho J, Benito R, Paules C. SARS-CoV-2 congenital infection and pre-eclampsia-like syndrome in dichorionic twins: A case report and review of the literature. Int J Gynaecol Obstet. 2021 Aug;154(2):370-372. doi: 10.1002/ijgo.13749. Epub 2021 Jun 9. PMID: 34009656; PMCID: PMC9087521.
Medel-Martínez A, Paules C, Perán M, Calvo P, Ruiz-Martinez S, Ormazabal Cundin M, Cebollada-Solanas A, Strunk M, Schoorlemmer J, Oros D, Fabre M. “Placental infection associated with SARS-CoV-2 wildtype variant and variants of concern”. Manuscript submitted.
Ruiz-Martinez, S.; Delgado, J. L.; Paules, C.; Cavallaro, A.; De Paco, C.; Villar, J.; Papageorghiou, A.; Oros, D.Clinical phenotypes for risk stratification in small-for-gestational-age fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692
Paules, Cristina; Perez Roche, Maria Teresa; Angel Marin, Miguel; Fayed, Nicolas; Garcia-Marti, Gracian; Lopez Pison, Javier; Oros, Daniel; Pueyo, Victoria. Different Brain Phenotypes in Magnetic Resonance Imaging of Healthy Children after Prenatal Insults. DIAGNOSTICS. 12, 2022.
Basso, A.; Youssef, L.; Nakaki, A.; Paules, C.; Miranda, J.; Casu, G.; Salazar, L.; Gratacos, E.; Eixarch, E.; Crispi, F.; Crovetto, F.. Fetal neurosonography at 31-35 weeks reveals altered cortical development in pre-eclampsia with and without small-for-gestational-age fetus. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692 DOI: 10.1002/uog.24853
Youssef, Lina; Crovetto, Francesca; Simoes, Rui Vasco; Miranda, Jezid; Paules, Cristina; Blasco, Miquel; Palomo, Marta; Garcia-Caldero, Hector; Tura-Ceide, Olga; Dantas, Ana Paula; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Campistol, Josep Maria; Garcia-Pagan, Joan Carles; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics. LIFE-BASEL. 12, 2022. DOI: 10.3390/life12010086
Cobo, Teresa; Aldecoa, Victoria; Bartha, Jose Luis; Bugatto, Fernando; Carrillo-Badillo, Maria Paz; Comas, Carmina; Diago-Almeda, Vicente; Ferrero, Silvia; Goya, Maria; Herraiz, Ignacio; Marti-Malgosa, Laia; Olivella, Anna; Paules, Cristina; Vives, Angels; Figueras, Francesc; Palacio, Montse; Gratacos, Eduard; OPTIM-PTL Grp. Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study). BMJ OPEN. 11, 2021. ISSN 2044-6055. DOI: 10.1136/bmjopen-2021-054711
Youssef, Lina; Miranda, Jezid; Blasco, Miquel; Paules, Cristina; Crovetto, Francesca; Palomo, Marta; Torramade-Moix, Sergi; Garcia-Caldero, Hector; Tura-Ceide, Olga; Paula Dantas, Ana; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Maria Campistol, Josep; Carles Garcia-Pagan, Joan; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322 DOI: 10.1038/s41598-021-82733-z
Crovetto F; Crispi F; Casas R; Martín-Asuero A; Borràs R; Vieta E; Estruch R; Gratacós E; IMPACT BCN Trial Investigators. Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial.JAMA. 326, pp. 2150 - 2160. 2021. ISSN 0098-7484 DOI: 10.1001/jama.2021.20178
Paules, C.; Miranda, J.; Policiano, C.; Crovetto, F.; Youssef, L.; Hahner, N.; Nakaki, A.; Crispi, F.; Gratacos, E.; Eixarch, E.. Fetal neurosonography detects differences in cortical development and corpus callosum in late-onset small fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 58, 2021. ISSN 0960-7692. DOI: 10.1002/uog.23592
Crovetto, Francesca; Crispi, Fatima; Borras, Roger; Paules, Cristina; Casas, Rosa; Martin-Asuero, Andres; Arranz, Angela; Vieta, Eduard; Estruch, Ramon; Gratacos, Eduard. Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): a study protocol for a randomized controlled trial. TRIALS. 22, 2021.
Youssef, Lina; Simoes, Rui V.; Miranda, Jezid; Garcia-Martin, Maria Luisa; Paules, Cristina; Crovetto, Francesca; Amigo, Nuria; Canellas, Nicolau; Gratacos, Eduard; Crispi, Fatima. Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322
Schoorlemmer, Jon; Macias-Redondo, Sofia; Strunk, Mark; Ramos-Ruiz, Ricardo; Calvo, Pilar; Benito, Rafael; Paules, Cristina; Oros, Daniel. Altered DNA methylation in human placenta after (suspected) preterm labor. EPIGENOMICS. 12, 2020. ISSN 1750-1911 DOI: 10.2217/epi-2019-0346
Youssef, Lina; Erlandsson, Lena; Akerstrom, Bo; Miranda, Jezid; Paules, Cristina; Crovetto, Francesca; Crispi, Fatima; Gratacos, Eduard; Hansson, Stefan R.. Hemopexin and alpha(1)-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction. PLOS ONE. 15, 2020. ISSN 1932-6203 DOI: 10.1371/journal.pone.0239030
Paules, Cristina; Youssef, Lina; Miranda, Jezid; Crovetto, Francesca; Maria Estanyol, Josep; Fernandez, Guerau; Crispi, Fatima; Gratacos, Eduard. Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction. SCIENTIFIC REPORTS. 10, 2020. ISSN 2045-2322
Lou-Mercade, A. C.; Gavin, O.; Oros, D.; Paules, C.; Saviron-Cornudella, R.; Mateo, P.; Paramo, J. A.; Ruiz-Martinez, S.. Prevention of thrombosis in pregnant women with suspected SARS-CoV-2 infection: clinical management algorithm. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 56, 2020. ISSN 0960-7692. DOI: 10.1002/uog.22096
Quintana LF; Palomo M; Blasco M; Molina P; Lozano M; Praga M; Torramade-Moix S; Martinez-Sanchez J; Cid J; Escolar G; Carreras E; Paules C; Crispi F; Poch E; Rodas L; Goma E; Morelle J; Espinosa M; Morales E; Avila A; Cabello V; Ariceta G; Chocron S; Manrique J; Barros X; Martin N; Huerta A; Fraga-Rodriguez GM; Cao M; Martin M; Romera AM; Moreso F; Manonelles A; Gratacos E; Pereira A; Campistol JM; Diaz-Ricart M. Complement Activation and Thrombotic Microangiopathies. Clin J Am Soc Nephrol.14 - 12, pp. 1719 - 1732. 12/2019. ISSN 1555-9041 DOI: 10.2215/CJN.05830519
Youssef L; Miranda J; Paules C; Garcia-Otero L; Vellve K; Kalapotharakos G; Sepulveda-Martinez A; Crovetto F; Gomez O; Gratacos E; Crispi F. Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. Am J Obstet Gynecol. 07/2019. DOI: doi: 10.1016/j.ajog.2019.07.025
Cristina Paules Tejero; Youssef L; Rovira C; Crovetto F; Nadal A; Peguero A; Figueras F; Eixarch E; Crispi f; Miranda J; Gratacos E. Distinctive patterns of placental lesions in preeclampsia versus fetal growth restriction and their association with fetoplacental Doppler. Ultrasound Obst Gyn. 05/2019.
Miranda J; Simoes R; Cristina Paules Tejero; Canueto D; Pardo-Cea M; Garcia-Martin ML; Crovetto F; Fuertes-Martin R; Domenech M; Gomez-Roig MD; Eixarch E; Estruch R; Hansson S; Amigo N; Canellas N; Crispi F; Gratacos E. Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction.Sci Rep-UK. 09/2018. DOI: 10.1038/s41598-018-31832-5
Fabre M, Calvo P, Ruiz-Martinez S, Peran M, Oros D, Medel-Martinez A, Strunk M, Benito Ruesca R, Schoorlemmer J, Paules C. Frequent Placental SARS-CoV-2 in Patients with COVID-19-Associated Hypertensive Disorders of Pregnancy. Fetal Diagn Ther. 2021;48(11-12):801-811. doi: 10.1159/000520179. Epub 2021 Nov 18. PMID: 34794139; PMCID: PMC8678236.
Abadía-Cuchí N, Ruiz-Martínez S, Fabre M, Mateo P, Remacha Sienes M, Ventura Faci P, Bueno Sancho J, Benito R, Paules C. SARS-CoV-2 congenital infection and pre-eclampsia-like syndrome in dichorionic twins: A case report and review of the literature. Int J Gynaecol Obstet. 2021 Aug;154(2):370-372. doi: 10.1002/ijgo.13749. Epub 2021 Jun 9. PMID: 34009656; PMCID: PMC9087521.
Medel-Martínez A, Paules C, Perán M, Calvo P, Ruiz-Martinez S, Ormazabal Cundin M, Cebollada-Solanas A, Strunk M, Schoorlemmer J, Oros D, Fabre M. “Placental infection associated with SARS-CoV-2 wildtype variant and variants of concern”. Manuscript submitted.
Ruiz-Martinez, S.; Delgado, J. L.; Paules, C.; Cavallaro, A.; De Paco, C.; Villar, J.; Papageorghiou, A.; Oros, D.Clinical phenotypes for risk stratification in small-for-gestational-age fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692
Paules, Cristina; Perez Roche, Maria Teresa; Angel Marin, Miguel; Fayed, Nicolas; Garcia-Marti, Gracian; Lopez Pison, Javier; Oros, Daniel; Pueyo, Victoria. Different Brain Phenotypes in Magnetic Resonance Imaging of Healthy Children after Prenatal Insults. DIAGNOSTICS. 12, 2022.
Basso, A.; Youssef, L.; Nakaki, A.; Paules, C.; Miranda, J.; Casu, G.; Salazar, L.; Gratacos, E.; Eixarch, E.; Crispi, F.; Crovetto, F.. Fetal neurosonography at 31-35 weeks reveals altered cortical development in pre-eclampsia with and without small-for-gestational-age fetus. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692 DOI: 10.1002/uog.24853
Youssef, Lina; Crovetto, Francesca; Simoes, Rui Vasco; Miranda, Jezid; Paules, Cristina; Blasco, Miquel; Palomo, Marta; Garcia-Caldero, Hector; Tura-Ceide, Olga; Dantas, Ana Paula; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Campistol, Josep Maria; Garcia-Pagan, Joan Carles; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics. LIFE-BASEL. 12, 2022. DOI: 10.3390/life12010086
Cobo, Teresa; Aldecoa, Victoria; Bartha, Jose Luis; Bugatto, Fernando; Carrillo-Badillo, Maria Paz; Comas, Carmina; Diago-Almeda, Vicente; Ferrero, Silvia; Goya, Maria; Herraiz, Ignacio; Marti-Malgosa, Laia; Olivella, Anna; Paules, Cristina; Vives, Angels; Figueras, Francesc; Palacio, Montse; Gratacos, Eduard; OPTIM-PTL Grp. Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study). BMJ OPEN. 11, 2021. ISSN 2044-6055. DOI: 10.1136/bmjopen-2021-054711
Youssef, Lina; Miranda, Jezid; Blasco, Miquel; Paules, Cristina; Crovetto, Francesca; Palomo, Marta; Torramade-Moix, Sergi; Garcia-Caldero, Hector; Tura-Ceide, Olga; Paula Dantas, Ana; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Maria Campistol, Josep; Carles Garcia-Pagan, Joan; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322 DOI: 10.1038/s41598-021-82733-z
Crovetto F; Crispi F; Casas R; Martín-Asuero A; Borràs R; Vieta E; Estruch R; Gratacós E; IMPACT BCN Trial Investigators. Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial.JAMA. 326, pp. 2150 - 2160. 2021. ISSN 0098-7484 DOI: 10.1001/jama.2021.20178
Paules, C.; Miranda, J.; Policiano, C.; Crovetto, F.; Youssef, L.; Hahner, N.; Nakaki, A.; Crispi, F.; Gratacos, E.; Eixarch, E.. Fetal neurosonography detects differences in cortical development and corpus callosum in late-onset small fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 58, 2021. ISSN 0960-7692. DOI: 10.1002/uog.23592
Crovetto, Francesca; Crispi, Fatima; Borras, Roger; Paules, Cristina; Casas, Rosa; Martin-Asuero, Andres; Arranz, Angela; Vieta, Eduard; Estruch, Ramon; Gratacos, Eduard. Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): a study protocol for a randomized controlled trial. TRIALS. 22, 2021.
Youssef, Lina; Simoes, Rui V.; Miranda, Jezid; Garcia-Martin, Maria Luisa; Paules, Cristina; Crovetto, Francesca; Amigo, Nuria; Canellas, Nicolau; Gratacos, Eduard; Crispi, Fatima. Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322
Schoorlemmer, Jon; Macias-Redondo, Sofia; Strunk, Mark; Ramos-Ruiz, Ricardo; Calvo, Pilar; Benito, Rafael; Paules, Cristina; Oros, Daniel. Altered DNA methylation in human placenta after (suspected) preterm labor. EPIGENOMICS. 12, 2020. ISSN 1750-1911 DOI: 10.2217/epi-2019-0346
Youssef, Lina; Erlandsson, Lena; Akerstrom, Bo; Miranda, Jezid; Paules, Cristina; Crovetto, Francesca; Crispi, Fatima; Gratacos, Eduard; Hansson, Stefan R.. Hemopexin and alpha(1)-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction. PLOS ONE. 15, 2020. ISSN 1932-6203 DOI: 10.1371/journal.pone.0239030
Paules, Cristina; Youssef, Lina; Miranda, Jezid; Crovetto, Francesca; Maria Estanyol, Josep; Fernandez, Guerau; Crispi, Fatima; Gratacos, Eduard. Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction. SCIENTIFIC REPORTS. 10, 2020. ISSN 2045-2322
Lou-Mercade, A. C.; Gavin, O.; Oros, D.; Paules, C.; Saviron-Cornudella, R.; Mateo, P.; Paramo, J. A.; Ruiz-Martinez, S.. Prevention of thrombosis in pregnant women with suspected SARS-CoV-2 infection: clinical management algorithm. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 56, 2020. ISSN 0960-7692. DOI: 10.1002/uog.22096
Quintana LF; Palomo M; Blasco M; Molina P; Lozano M; Praga M; Torramade-Moix S; Martinez-Sanchez J; Cid J; Escolar G; Carreras E; Paules C; Crispi F; Poch E; Rodas L; Goma E; Morelle J; Espinosa M; Morales E; Avila A; Cabello V; Ariceta G; Chocron S; Manrique J; Barros X; Martin N; Huerta A; Fraga-Rodriguez GM; Cao M; Martin M; Romera AM; Moreso F; Manonelles A; Gratacos E; Pereira A; Campistol JM; Diaz-Ricart M. Complement Activation and Thrombotic Microangiopathies. Clin J Am Soc Nephrol.14 - 12, pp. 1719 - 1732. 12/2019. ISSN 1555-9041 DOI: 10.2215/CJN.05830519
Youssef L; Miranda J; Paules C; Garcia-Otero L; Vellve K; Kalapotharakos G; Sepulveda-Martinez A; Crovetto F; Gomez O; Gratacos E; Crispi F. Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. Am J Obstet Gynecol. 07/2019. DOI: doi: 10.1016/j.ajog.2019.07.025
Cristina Paules Tejero; Youssef L; Rovira C; Crovetto F; Nadal A; Peguero A; Figueras F; Eixarch E; Crispi f; Miranda J; Gratacos E. Distinctive patterns of placental lesions in preeclampsia versus fetal growth restriction and their association with fetoplacental Doppler. Ultrasound Obst Gyn. 05/2019.
Miranda J; Simoes R; Cristina Paules Tejero; Canueto D; Pardo-Cea M; Garcia-Martin ML; Crovetto F; Fuertes-Martin R; Domenech M; Gomez-Roig MD; Eixarch E; Estruch R; Hansson S; Amigo N; Canellas N; Crispi F; Gratacos E. Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction.Sci Rep-UK. 09/2018. DOI: 10.1038/s41598-018-31832-5
Otra actividad
Proyectos:
“Impacto de la amenaza de parto prematuro en la programación cardiovascular y metabólica desde la vida fetal hasta la infancia”. Instituto de Investigación Sanitaria Carlos III (PI20/00741).
Valoración global de salud en la infancia tras sufrir una amenaza de parto pretérmino “Superkids study”.
Caracterización fenotípica de la diabetes gestacional: abordaje personalizado de las complicaciones materno-fetales a corto y medio plazo (Pheno-GestDM). Solicitado en esta convocatoria Proyectos de I+D+I en salud. (AES 2023)
Tesis:
La IP dirige la tesis doctoral de Ana Medel, Jesús González y Natalia Abadía.
“Impacto de la amenaza de parto prematuro en la programación cardiovascular y metabólica desde la vida fetal hasta la infancia”. Instituto de Investigación Sanitaria Carlos III (PI20/00741).
Valoración global de salud en la infancia tras sufrir una amenaza de parto pretérmino “Superkids study”.
Caracterización fenotípica de la diabetes gestacional: abordaje personalizado de las complicaciones materno-fetales a corto y medio plazo (Pheno-GestDM). Solicitado en esta convocatoria Proyectos de I+D+I en salud. (AES 2023)
Tesis:
La IP dirige la tesis doctoral de Ana Medel, Jesús González y Natalia Abadía.