Sobre el grupo
Investigador Principal
Diego Sánchez Martínez
Equipo
Iñaki Arretxe García, Lydia Minguell Soto, Sofía Blasco Sebastián
Edificio CIBA
Líneas de Investigación
Inmunoterapia celular avanzada con especial interés en células CAR-T y CAR-NK y sus mecanismos
citotóxicos empleados en eliminar tumores
Origen molecular de la generación del síndrome de liberación de citoquinas (CRS) y neurotoxicidad
(ICANS) provocado por el tratamiento con células CAR-T
Combinación de células CAR-T con inhibidores de proteínas antiapoptóticas mutadas para aumentar
la capacidad citotóxica frente a tumores de mal pronóstico
Publicaciones mas relevantes
Cecilia Pesini; Laura Artal; Jorge Paúl Bernal; Diego Sánchez-Martínez*; Julián Pardo; Ariel Ramírez-Labrada. 2024. In-depth analysis of the interplay between Oncogenic Mutations and NK Cell- Mediated Cancer Surveillance in Solid Tumors. Oncoimmunology. 13(1):2379062. https://doi.org/10.1080/2162402X.2024.2379062
Sofia Mensurado; Carolina Condeço; Diego Sánchez-Martínez; et al; Bruno Silva-Santos. 2024. CD155/PVR determines Acute Myeloid Leukemia targeting by Delta One T cells. Blood. pp. In press. 1st decile. (2024)
Anaïs Jimenez-Reinoso; Nestor Tirado; Alba Martínez-Moreno; et al; Diego Sánchez-Martínez*. 2022. Efficient preclinical treatment of cortical T cell acute lymphoblastic leukemia with T lymphocytes secreting anti-CD1a T cell engagers. Journal for Immunotherapy of Cancer. 10-12, pp.e005333. doi:10.1136/jitc-2022-005333. 1st quartile. (2022)
Diego Sánchez-Martínez*; Néstor Tirado; Sofia Mensurado; et al; Pablo Menendez. 2022. Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid Leukemia. Journal for Immunotherapy of Cancer. 10-9, pp.e005400. doi: 10.1136/jitc-2022-005400. 1st quartile. (2022)
Samanta Romina Zanetti; Talia Velasco-Hernandez; …; Diego Sanchez-Martinez; et al; Pablo Menendez;. 20. A novel and efficient tandem CD19- and CD22-directed CAR for B cell ALL. Molecular Therapy. 30. https://doi.org/10.1016/j.ymthe.2021.08.03. 1st quartile. (2021)
Diego Sánchez-Martínez*; Francisco Gutiérrez-Agüera;Paola Romecin; et al; Pablo Menéndez. 2021. Enforced sialyl-Lewis-X (sLeX) displayin E-selectin ligands by exofucosylation is dispensable for CD19-CAR T-cell activityand bone marrow homing. Clinical and Translational Medicine. 11-2, pp.e280. doi:10.1002/ctm2.280. 1st quartile. (2021)
Matteo L Baroni; Diego Sánchez-Martínez; Francisco Gutierrez-Agüera; et al; Pablo Menéndez. 2020. 4-1BB-based andCD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo. Journal for Immunotherapy of Cancer. 8-1, pp.e000845. doi: 10.1136/jitc-2020-000845. 1st quartile. (2020)
Velasco-Hernandez T; Zanetti SR; Roca-Ho H; …; Sánchez-Martínez D ; et al; Menéndez P. Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope. Journal for Immunotherapy of Cancer. 8-2. https://doi.org/10.1136/jitc2020-000896. 1st quartile. (2020)
Tania Calvo; Chantal Reina-Ortiz; David Giraldos; …; Diego Sánchez-Martínez; et al; Alberto Anel. Expanded and activated allogeneic NK cells are cytotoxic against B‑chronic lymphocytic leukemia (B‑CLL) cells with sporadic cases of resistance. Scientific Reports. 10-1, pp.19398. 1st quartile. (2020)
Clara Bueno; Talia Velasco; Francisco Gutierrez-Agüera; …; Diego Sanchez-Martinez; et al; Pablo Menendez; CD133-directed CART cells for MLL B-cell ALL: on target, off-tumor myeloablative toxicity. Leukemia. 33-8, pp.2090-2125. 1st decile. (2019)
Diego Sánchez-Martínez*; Matteo L Baroni; Francisco Gutierrez-Agüera; et al; Pablo Menendez. 2019. Fratricide-resistant CD1a-specific CAR T-cells for the treatment of cortical T-cell acute lymphoblastic leukemia. Blood. 133-21, pp.2291-2304. https://doi.org/10.1182/blood-2018-10-882944. 1st decile. (2019)
Belen Lopez-Millan; Diego Sanchez-Martinez; Heleia Roca-Ho; et al; Pablo Menendez. 2019. NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia. Leukemia. 33(7):1557-1569.. https://doi.org/10.1038/s41375-018-0353-0. 1st decile. (2019)
Otra actividad
Pablo Menendez Bujan; Diego Sanchez Martinez; Néstor Tirado Cabrera; Narciso Fernández Fuertes; Victor Manuel Diaz Cortes. EP23382147.9. CCR9 TARGETING MOIETY FOR THE TREATMENT OF CCR9-POSITIVE CANCER Spain. 15/02/2023.
Laura Garcia Perez; Victor Manuel Diaz Cortes; Pablo Menendez Bujan; Diego Sanchez Martinez. EP22382174.5. HUMANIZED CD1a TARGETING MOIETY FOR THE TREATMENT OF CD1APOSITIVE CANCER Spain. 28/02/2022.
Pablo Menendez Bujan; Talia Velasco Hernandez; Samanta Romina Zanetti; Pablo Engel Rocamora; Diego Sanchez Martinez; Francisco Gutierrez Agüera. EP20382175.6. CD22 Targeting-moiety for the treatment of B-cell acute lymphoblastic Leukemia (B-ALL) Spain. 11/03/2020.
Heleia Roca Ho; Francisco Gutierrez Agüera; Clara Bueno Uroz; Pablo Menendez Bujan; Diego
Sanchez Martinez. EP19382104.8. CAR T-cells for the treatment of CD1a-positive cancer Spain. 14/02/2019.