Sobre el grupo
Investigador Principal
Javier Sancho Sanz
Equipo
Ana Flores Charlez, Antonio Hidalgo Toledo, Helena García Cebollada, Jose Alberto Carrodeguas Villar, Juan José Galano Frutos, Patricia Bruñén Fau, Ramón Hurtado Guerrero, Ritwik Maity
Universidad de Zaragoza
Líneas de Investigación
Biofisica del receptor de LDL
Diferenciación selectiva de células madre
Estabilidad de proteínas y enfermedad
Identificación y desarrollo de compuestos bioactivos (antimicrobianos, antivirales, antifúngicos, anticancerígenos, chaperonas farmacológicas, inductores selectivos de apoosis, inhibidores de agregación de péptído Ab)
Interacciones funcionales
Publicaciones más relevantes
Pujols J, Pena-Diaz S, Lazaro D, Peccati F, Pinheiro F, Gonzalez D, Carija A, Navarro S, Conde-Gimenez M, Garcia J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro T, Dalfo E, Ventura S. Small molecule inhibits alpha-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc. Natl. Acad. Sci. U. S. A.. 2018. 115(41): 10481 - 10486. 10.1073/pnas.1804198115.
Latorre-Muro P, Baeza J, Armstrong E, Hurtado-Guerrero R, Corzana F, Wu L, Sinclair D, Lopez-Buesa P, Carrodeguas J, Denu J. Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Mol. Cell. 2018. 71(5). 10.1016/j.molcel.2018.07.031.
Ruiz-Partida R, Prado S, Villarroya M, Velazquez-Campoy A, Bravo J, Armengod M. An Alternative Homodimerization Interface of MnmG Reveals a Conformational Dynamics that Is Essential for Its tRNA Modification Function. J. Mol. Biol.. 2018. 430(17): 2822 - 2842. 10.1016/j.jmb.2018.05.035.
Hernando D, Roca S, Sancho J, Alesanco A, Bailon R. Validation of the Apple Watch for Heart Rate Variability Measurements during Relax and Mental Stress in Healthy Subjects. Sensors. 2018. 18(8): 2619. 10.3390/s18082619.
Velazquez-Campoy A, Vega S, Sanchez-Gracia O, Lanas A, Rodrigo A, Kaliappan A, Hall M, Nguyen T, Brock G, Chesney J, Garbett N, Abian O. Thermal liquid biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study. Biochim. Biophys. Acta-Gen. Subj.. 2018. 1862(8): 1701 - 1710. 10.1016/j.bbagen.2018.04.020.
Santofimia-Castano P, Rizzuti B, Abian O, Velazquez-Campoy A, Iovanna J, Neira J. Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1). Biochim. Biophys. Acta-Gen. Subj.. 2018. 1862(6): 1283 - 1295. 10.1016/j.bbagen.2018.03.009.
Sebastian M, Velazquez-Campoy A, Medina M. The RFK catalytic cycle of the pathogen Streptococcus pneumoniae shows species-specific features in prokaryotic FMN synthesis. J. Enzym. Inhib. Med. Chem.. 2018. 33(1): 842 - 849. 10.1080/14756366.2018.1461857.
Elena-Real C, Diaz-Quintana A, Gonzalez-Arzola K, Velazquez-Campoy A, Orzaez M, Lopez-Rivas A, Gil-Caballero S, De la Rosa M, Diaz-Moreno I. Cytochrome c speeds up caspase cascade activation by blocking 14-3-3 epsilon-dependent Apaf-1 inhibition. Cell Death Dis.. 2018. 9: 365. 10.1038/s41419-018-0408-1.
de Barros A, Takeda A, Dreyer T, Velazquez-Campoy A, Kobe B, Fontes M. DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie. 2018. 146: 87 - 96. 10.1016/j.biochi.2017.11.013.
Neira J, Hornos F, Cozza C, Camara-Artigas A, Abian O, Velazquez-Campoy A. The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments. Arch. Biochem. Biophys.. 2018. 639: 26 - 37. 10.1016/j.abb.2017.12.017.
Koskela M, Dahlstrom K, Goni G, Lehtimaki N, Nurmi M, Velazquez-Campoy A, Hanke G, Bolter B, Salminen T, Medina M, Mulo P. Arabidopsis FNRL protein is an NADPH-dependent chloroplast oxidoreductase resembling bacterial ferredoxin-NADP(+) reductases. Physiol. Plant.. 2018. 162(2): 177 - 190. 10.1111/ppl.12621.
Sein-Echaluce V, Pallares M, Lostao A, Yruela I, Velazquez-Campoy A, Peleato M, Fillat M. Molecular basis for the integration of environmental signals by FurB from Anabaena sp PCC 7120. Biochem. J.. 2018. 475: 151 - 168. 10.1042/BCJ20170692.
Dominguez-Martin M, Lopez-Lozano A, Claveria-Gimeno R, Velazquez-Campoy A, Seidel G, Burkovski A, Diez J, Garcia-Fernandez J. Differential NtcA Responsiveness to 2-Oxoglutarate Underlies the Diversity of C/N Balance Regulation in Prochlorococcus. Front. Microbiol.. 2018. 8: 2641. 10.3389/fmicb.2017.02641.