Título
UNLOOC: Desbloquear el contenido de datos de los Organ-On-Chips (Unlocking data content of Organ-On-Chips) - GA: 101140192
Descripción
Before drugs can proceed to clinical trials on human subjects, animal models have traditionally been used to validate the effectiveness, toxicity and pharmacokinetics of the drug. However, use of animal models comes with many potential challenges, such as lower predictability to humans, high failure rates in clinical trials, excessive costs in drug development and risk of death caused by unwanted side effects in approved drugs.
UNLOOC aims to develop groundbreaking Organ-on-Chips (OOC) technologies to mitigate the challenges posed by use of animals in drug development and testing. Direct use of human cells is a real game changer, bridging the gender gap and allowing personalized medicine.
Objetivos y Resultados
The UNLOOC project tackles the challenge inherent in animal testing of drugs, aiming to demonstrate through its five novel use cases how the groundbreaking methods using Organ-on-a-Chip (OOC) technology enable the development of more effective treatments, leaving animal subjects out of the equation. The OOC technology to be developed in the UNLOOC project will not only enable controlled drug testing, but also the modelling of disease pathophysiology.
Use case 1: Developing human OOC diversity panels and demonstrating the impact in the drug efficacy and safety testing using advanced multi-parametric AI-based analysis.
Use case 2a: Standardized Single-Organ Smart OOC Multi-well Plate (SOMP) evaluated with epithelium-on-chip and cancer-on-chip.
Use case 2b: Multi-Organ Smart OOC Multi-well Plate (MOMP) with integrated sensors for the prediction of oral drug absorption.
Use case 3: Skin-on-Chip for Pharma Applications and Chemical Compound Testing.
Use case 4: Integrated fluidic control, sensing, and incubation system for the BBB-on-Chip
Use case 5: Lung-on-Chip.
IP IIS Aragón
Ignacio OCHOA GARRIDO
Organismo Financiador
El proyecto Unlocking data content of Organ-On-Chips (UNLOOC), código de expediente 101140192, de la convocatoria HORIZON-KDT-JU-2023-1-IA del Programa Marco de Investigación de la Unión Europea (Horizonte Europa) y de por la de la Convocatoria Proyectos de Colaboración Internacional de la Agencia Estatal de Investigación, está financiado por:
Europa: This project is supported by the Chips Joint Undertaking and its members Belgium, Germany, Hungary, Ireland, Italy, the Netherlands, Portugal, Romania, Spain, Switzerland. This work includes top-up funding from the Swiss State Secretariat for Education, Research and Innovation (SERI).
España: Proyecto PCI2024-153529 financiado por MICIU/AEI/10.13039/501100011033 y Cofinanciado por la Unión Europea
Coordinador
Microfluidic ChipShop GMBH
Socios
51 socios de 10 países europeos diferentes
Duración
01/05/2024 – 30/04/2027
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